Jump to main content
Jump to site search

Issue 55, 2014
Previous Article Next Article

Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes

Author affiliations

Abstract

The development of the first redox-free protocol for the Mitsunobu reaction is described. This has been achieved by exploiting triphenylphosphine oxide – the unwanted by-product in the conventional Mitsunobu reaction – as the precursor to the active P(V) coupling reagent. Multinuclear NMR studies are consistent with hydroxyl activation via an alkoxyphosphonium salt.

Graphical abstract: Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 24 Mar 2014, accepted on 16 May 2014 and first published on 19 May 2014


Article type: Communication
DOI: 10.1039/C4CC02171A
Citation: Chem. Commun., 2014,50, 7340-7343
  •   Request permissions

    Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes

    X. Tang, C. Chapman, M. Whiting and R. Denton, Chem. Commun., 2014, 50, 7340
    DOI: 10.1039/C4CC02171A

Search articles by author