Jump to main content
Jump to site search

Issue 53, 2014
Previous Article Next Article

Synthesis of spiro[isoquinolinone-4,2′-oxiranes] and isoindolinones via a multicomponent reaction of 2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile

Author affiliations

Abstract

Efficient synthesis of spiro[isoquinolinone-4,2′-oxiranes] was achieved based on a multicomponent one-pot reaction of readily available cis-2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile at room temperature. However, in the reaction with trans-2-acetyl-oxirane-2-carboxamide substrates, 3-iminoisoindolinones were obtained in moderate to high yields.

Graphical abstract: Synthesis of spiro[isoquinolinone-4,2′-oxiranes] and isoindolinones via a multicomponent reaction of 2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Mar 2014, accepted on 09 May 2014 and first published on 12 May 2014


Article type: Communication
DOI: 10.1039/C4CC02141J
Citation: Chem. Commun., 2014,50, 6995-6997
  •   Request permissions

    Synthesis of spiro[isoquinolinone-4,2′-oxiranes] and isoindolinones via a multicomponent reaction of 2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile

    B. Liu, E. Wei, S. Lin, B. Zhao and F. Liang, Chem. Commun., 2014, 50, 6995
    DOI: 10.1039/C4CC02141J

Search articles by author

Spotlight

Advertisements