Jump to main content
Jump to site search

Issue 43, 2014
Previous Article Next Article

Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

Author affiliations

Abstract

The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (19F) magnetic resonance spectroscopy (19F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B122−-core via suitable linkers. The 19F-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.

Graphical abstract: Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 21 Mar 2014, accepted on 15 Apr 2014 and first published on 15 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC02126F
Citation: Chem. Commun., 2014,50, 5793-5795
  •   Request permissions

    Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

    L. N. Goswami, A. A. Khan, S. S. Jalisatgi and M. F. Hawthorne, Chem. Commun., 2014, 50, 5793
    DOI: 10.1039/C4CC02126F

Search articles by author