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Issue 43, 2014
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Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

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Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Graphical abstract: Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

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Publication details

The article was received on 18 Mar 2014, accepted on 05 Apr 2014 and first published on 07 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC02011A
Citation: Chem. Commun., 2014,50, 5741-5744
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    Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

    Y. O. Lee, J. Shin, C. Yi, Y. H. Lee, N. Sohn, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 5741
    DOI: 10.1039/C4CC02011A

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