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Issue 52, 2014
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Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

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Abstract

Recently developed chemical ligation protocols were elaborated for rapid N-terminal protein PEGylation. We introduce a PEG-salicylaldehyde ester and demonstrate its site-specific ligation to the N-terminus of the RNase S protein and to the therapeutic polypeptide PTH (1–34).

Graphical abstract: Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

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Publication details

The article was received on 14 Mar 2014, accepted on 29 Apr 2014 and first published on 19 May 2014


Article type: Communication
DOI: 10.1039/C4CC01928H
Citation: Chem. Commun., 2014,50, 6909-6912
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    Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

    P. M. Levine, T. W. Craven, R. Bonneau and K. Kirshenbaum, Chem. Commun., 2014, 50, 6909
    DOI: 10.1039/C4CC01928H

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