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Issue 41, 2014
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Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

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Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

Graphical abstract: Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

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Publication details

The article was received on 14 Mar 2014, accepted on 03 Apr 2014 and first published on 10 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01924E
Citation: Chem. Commun., 2014,50, 5487-5489
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    Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

    N. L. Brock, A. Nikolay and J. S. Dickschat, Chem. Commun., 2014, 50, 5487
    DOI: 10.1039/C4CC01924E

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