Issue 41, 2014

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

Graphical abstract: Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2014
Accepted
03 Apr 2014
First published
10 Apr 2014

Chem. Commun., 2014,50, 5487-5489

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

N. L. Brock, A. Nikolay and J. S. Dickschat, Chem. Commun., 2014, 50, 5487 DOI: 10.1039/C4CC01924E

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