Issue 43, 2014

Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael addition of 3-substituted oxindoles to nitroolefins

Abstract

The Michael addition of 3-substituted oxindoles to nitroolefins was catalyzed by a novel tartrate-derived guanidine in high yield with excellent diastereo- and enantioselectivity. This method showed an extraordinarily broad substrate scope in terms of both reaction partners.

Graphical abstract: Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael addition of 3-substituted oxindoles to nitroolefins

Supplementary files

Article information

Article type
Communication
Submitted
11 Mar 2014
Accepted
04 Apr 2014
First published
08 Apr 2014

Chem. Commun., 2014,50, 5760-5762

Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael addition of 3-substituted oxindoles to nitroolefins

L. Zou, X. Bao, Y. Ma, Y. Song, J. Qu and B. Wang, Chem. Commun., 2014, 50, 5760 DOI: 10.1039/C4CC01817F

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