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Issue 82, 2014
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A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

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Abstract

The InCl3-catalyzed sequential multicomponent reaction between 2-furfurylamine, β-dicarbonyl compounds and α,β-unsaturated aldehydes in ethanol, followed by microwave irradiation in solvent-free conditions, afforded good to excellent yields of highly substituted pyridines, with loss of a 2-furylmethyl side chain. The method was also adapted to the synthesis of quinolones, isoquinolines, phenanthridines and more complex fused pyridine systems.

Graphical abstract: A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

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Publication details

The article was received on 10 Mar 2014, accepted on 16 Apr 2014 and first published on 16 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01791A
Citation: Chem. Commun., 2014,50, 12270-12272
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    A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

    V. P. A. Raja, G. Tenti, S. Perumal and J. C. Menéndez, Chem. Commun., 2014, 50, 12270
    DOI: 10.1039/C4CC01791A

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