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Issue 46, 2014
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An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

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Abstract

We disclose a novel efficient enantioselective organocatalytic cascade reaction for the preparation of δ-lactones in good to excellent yields (69–93%) and with high to excellent enantioselectivities (88–96% ee).

Graphical abstract: An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

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Publication details

The article was received on 07 Mar 2014, accepted on 15 Apr 2014 and first published on 15 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01736F
Citation: Chem. Commun., 2014,50, 6137-6140
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    An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

    Q. Ren, S. Sun, J. Huang, W. Li, M. Wu, H. Guo and J. Wang, Chem. Commun., 2014, 50, 6137
    DOI: 10.1039/C4CC01736F

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