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Issue 49, 2014
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EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

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Abstract

An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

Graphical abstract: EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

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Publication details

The article was received on 03 Mar 2014, accepted on 28 Mar 2014 and first published on 28 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01589D
Citation: Chem. Commun., 2014,50, 6517-6519
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    EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

    L. Jiang, Y. Lui, H. Li, C. Chan, R. Lan, W. Chan, T. C. Lau, G. S. Tsao, N. Mak and K. Wong, Chem. Commun., 2014, 50, 6517
    DOI: 10.1039/C4CC01589D

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