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Issue 46, 2014
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Rh(III)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water

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Abstract

A novel and direct approach to synthesize 1-aminoindole derivatives by Rh(III)-catalyzed cyclization of 2-acetyl-1-arylhydrazines with diazo compounds via aryl C–H activation has been developed. This intermolecular annulation involving tandem C–H activation, cyclization and condensation steps proceeds efficiently in water, obviates the need of external oxidants, and displays a broad substituent scope.

Graphical abstract: Rh(iii)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water

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Publication details

The article was received on 28 Feb 2014, accepted on 14 Apr 2014 and first published on 14 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01520G
Citation: Chem. Commun., 2014,50, 6130-6133
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    Rh(III)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water

    Y. Liang, K. Yu, B. Li, S. Xu, H. Song and B. Wang, Chem. Commun., 2014, 50, 6130
    DOI: 10.1039/C4CC01520G

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