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Issue 35, 2014
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A gold-catalysed imine–propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism

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Abstract

The gold-catalysed coupling reaction between propargylamine-derived imines and propargylamine exclusively afforded pyrazines. Besides, in order to understand the mechanism of this sequence, deuterium labeling and computational studies have been performed.

Graphical abstract: A gold-catalysed imine–propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism

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Publication details

The article was received on 26 Feb 2014, accepted on 12 Mar 2014 and first published on 13 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01485E
Citation: Chem. Commun., 2014,50, 4567-4570
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    A gold-catalysed imine–propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism

    B. Alcaide, P. Almendros, J. M. Alonso, I. Fernández, G. Gómez-Campillos and M. R. Torres, Chem. Commun., 2014, 50, 4567
    DOI: 10.1039/C4CC01485E

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