n-Bu4NI-catalyzed selective dual amination of sp3 C–H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale

Dan Zhao; Teng Wang; Qi Shen; Jian-Xin Li

doi:10.1039/C4CC01444H

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n-Bu₄NI-catalyzed selective dual amination of sp³ C–H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale†

Dan Zhao,^a Teng Wang,^a Qi Shen^a and Jian-Xin Li*^a

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* Corresponding authors

^a State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: lijxnju@nju.edu.cn
Fax: +86-25-83686419
Tel: +86-25-83686419

Abstract

An n-Bu₄NI catalyzed domino reaction that involves selective dual amination of sp³ C–H bonds has been developed. The protocol affords a facile and efficient approach to the synthesis of imidazo[1,5-c]quinazolines under mild conditions.

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Article information

DOI: https://doi.org/10.1039/C4CC01444H
Article type: Communication
Submitted: 25 Feb 2014
Accepted: 03 Mar 2014
First published: 03 Mar 2014

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Chem. Commun., 2014,50, 4302-4304

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n-Bu₄NI-catalyzed selective dual amination of sp³ C–H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale

D. Zhao, T. Wang, Q. Shen and J. Li, Chem. Commun., 2014, 50, 4302 DOI: 10.1039/C4CC01444H

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