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Issue 41, 2014
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Biocatalytic amide condensation and gelation controlled by light

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Abstract

We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans-Azo-YF-NH2 in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis-Azo-Y + F-NH2) with consequent gel dissolution.

Graphical abstract: Biocatalytic amide condensation and gelation controlled by light

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Publication details

The article was received on 24 Feb 2014, accepted on 25 Mar 2014 and first published on 25 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01431F
Citation: Chem. Commun., 2014,50, 5462-5464
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    Biocatalytic amide condensation and gelation controlled by light

    J. K. Sahoo, S. K. M. Nalluri, N. Javid, H. Webb and R. V. Ulijn, Chem. Commun., 2014, 50, 5462
    DOI: 10.1039/C4CC01431F

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