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Issue 63, 2014
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Clipping of predetermined fragments from the human genome by S1 nuclease–PNA combinations

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Abstract

By combining S1 nuclease with two strands of pseudo-complementary peptide nucleic acid (pcPNA), the whole human genome was selectively cut at targeted sites, and desired fragments were clipped from the genome.

Graphical abstract: Clipping of predetermined fragments from the human genome by S1 nuclease–PNA combinations

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Publication details

The article was received on 24 Feb 2014, accepted on 13 Jun 2014 and first published on 13 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC01420K
Citation: Chem. Commun., 2014,50, 8674-8676
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    Clipping of predetermined fragments from the human genome by S1 nuclease–PNA combinations

    X. Li, S. Muneoka, N. Shigi, J. Sumaoka and M. Komiyama, Chem. Commun., 2014, 50, 8674
    DOI: 10.1039/C4CC01420K

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