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Issue 41, 2014
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Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

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Abstract

The chiral gold(I) complex enables enantioselective cycloisomerization–amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropisomer.

Graphical abstract: Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

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Publication details

The article was received on 23 Feb 2014, accepted on 19 Mar 2014 and first published on 20 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01397B
Citation: Chem. Commun., 2014,50, 5451-5454
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    Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

    R. Guo, K. Li, B. Liu, H. Zhu, Y. Fan and L. Gong, Chem. Commun., 2014, 50, 5451
    DOI: 10.1039/C4CC01397B

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