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Issue 37, 2014
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Detection and quantification of the Bcr/Abl chimeric protein on biochips using LDI-TOF MS

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Abstract

The Bcr/Abl chimeric protein was captured by two antibodies, anti-Bcr on gold nanoparticles (AuNPs) and anti-Abl on a biochip, in a sandwich assay format. The presence of the Bcr/Abl in cells was then verified by amplified LDI-TOF MS signals, and relative amounts were quantified using AuNPs coated with deuterated alkanethiols as an internal standard.

Graphical abstract: Detection and quantification of the Bcr/Abl chimeric protein on biochips using LDI-TOF MS

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Publication details

The article was received on 20 Feb 2014, accepted on 17 Mar 2014 and first published on 18 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01332H
Citation: Chem. Commun., 2014,50, 4831-4834
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    Detection and quantification of the Bcr/Abl chimeric protein on biochips using LDI-TOF MS

    S. Hong, J. I. Kim, H. Kang, S. Yoon, D. Kim, W. Jung and W. Yeo, Chem. Commun., 2014, 50, 4831
    DOI: 10.1039/C4CC01332H

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