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Issue 46, 2014
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Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

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Abstract

We have synthesized and evaluated two self-immobilizing, turn-on fluorescent probes carrying a coumarin molecular framework for imaging intracellular human steroid sulfatase (STS) activity. The 8-fluoromethyl coumarin derivative, which gives stronger fluorescence response in the incubation study with STS preparations, was successfully applied to visualize STS activity in cells.

Graphical abstract: Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

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Publication details

The article was received on 18 Feb 2014, accepted on 16 Apr 2014 and first published on 16 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01282H
Citation: Chem. Commun., 2014,50, 6116-6119
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    Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

    C. Tai, C. Lu, S. Wu and L. Lo, Chem. Commun., 2014, 50, 6116
    DOI: 10.1039/C4CC01282H

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