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Issue 49, 2014
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TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

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Abstract

Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.

Graphical abstract: TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

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Publication details

The article was received on 16 Feb 2014, accepted on 27 Mar 2014 and first published on 27 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01210K
Citation: Chem. Commun., 2014,50, 6454-6457
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    TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

    W. Yi, X. Yu, B. Wang, J. Zhang, Q. Yu, X. Zhou and X. Yu, Chem. Commun., 2014, 50, 6454
    DOI: 10.1039/C4CC01210K

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