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Issue 31, 2014
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A novel P450-based biocatalyst for the selective production of chiral 2-alkanols

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Abstract

A P450 monooxygenase from Nocardia farcinica (CYP154A8) catalyses the stereo- and regioselective hydroxylation of n-alkanes, still a challenging task in chemical catalysis. In a biphasic reaction system, the regioselectivity for the C2-position of C7–C9 alkanes was over 90%. The enzyme showed strict S-selectivity for all tested substrates, with enantiomeric excess (ee) of up to 91%.

Graphical abstract: A novel P450-based biocatalyst for the selective production of chiral 2-alkanols

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Publication details

The article was received on 24 Jan 2014, accepted on 24 Feb 2014 and first published on 25 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00647J
Citation: Chem. Commun., 2014,50, 4089-4091
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    A novel P450-based biocatalyst for the selective production of chiral 2-alkanols

    C. J. von Bühler and V. B. Urlacher, Chem. Commun., 2014, 50, 4089
    DOI: 10.1039/C4CC00647J

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