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Issue 42, 2014
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Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

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Abstract

Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

Graphical abstract: Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

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Publication details

The article was received on 24 Jan 2014, accepted on 17 Feb 2014 and first published on 17 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00620H
Citation: Chem. Commun., 2014,50, 5547-5550
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    Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

    A. Popat, S. Jambhrunkar, J. Zhang, J. Yang, H. Zhang, A. Meka and C. Yu, Chem. Commun., 2014, 50, 5547
    DOI: 10.1039/C4CC00620H

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