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Issue 28, 2014
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PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

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Abstract

A simple and readily available PdCl2 catalyzed carbamate synthesis method via isocyanate generation and application in situ has been developed. This chemistry provides an efficient and practical approach to synthesize carbamates from simple organic azides, CO atmosphere and alcohols. The broad scope, mild and neutral conditions, and only N2 as the byproduct make this transformation very useful. Moreover, simple examples of modification of bioactive molecules and construction of macrocycles were achieved through this protocol.

Graphical abstract: PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

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Publication details

The article was received on 21 Jan 2014, accepted on 11 Feb 2014 and first published on 12 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00538D
Citation: Chem. Commun., 2014,50, 3706-3709
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    PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

    L. Ren and N. Jiao, Chem. Commun., 2014, 50, 3706
    DOI: 10.1039/C4CC00538D

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