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Issue 56, 2014
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The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

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Abstract

Asplatin, a fusion of aspirin and cisplatin, exhibits significant cytotoxicity in tumor cells and almost fully overcomes the drug resistance of cisplatin resistant cells. Asplatin is highly accumulated in cancer cells and is activated upon the reduction by ascorbic acid.

Graphical abstract: The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

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Publication details

The article was received on 17 Jan 2014, accepted on 27 Feb 2014 and first published on 28 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00419A
Citation: Chem. Commun., 2014,50, 7427-7430
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    The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

    Q. Cheng, H. Shi, H. Wang, Y. Min, J. Wang and Y. Liu, Chem. Commun., 2014, 50, 7427
    DOI: 10.1039/C4CC00419A

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