Jump to main content
Jump to site search

Issue 22, 2014
Previous Article Next Article

Calcium mediated formation of phosphorylcholine-based polyplexes for efficient knockdown of epidermal growth factor receptors (EGFR) in HeLa cells

Author affiliations

Abstract

2-Methacryloxyethyl phosphorylcholine (MPC) materials are well studied due to their excellent biocompatibility and are currently being used in many clinical applications. In this study, MPC based homopolymers and copolymers are prepared and are subsequently evaluated for their charge inversion properties in the presence of cations and subsequent DNA binding efficacies. These polymers are then studied for their epidermal growth factor receptor (EGFR) specific siRNA delivery in HeLa cells. The homopolymers of MPC and their copolymers show efficient EGFR knockdown efficacies in HeLa cells both in the presence and absence of serum proteins.

Graphical abstract: Calcium mediated formation of phosphorylcholine-based polyplexes for efficient knockdown of epidermal growth factor receptors (EGFR) in HeLa cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jan 2014, accepted on 28 Jan 2014 and first published on 28 Jan 2014


Article type: Communication
DOI: 10.1039/C4CC00181H
Citation: Chem. Commun., 2014,50, 2943-2946
  •   Request permissions

    Calcium mediated formation of phosphorylcholine-based polyplexes for efficient knockdown of epidermal growth factor receptors (EGFR) in HeLa cells

    M. Ahmed, K. Ishihara and R. Narain, Chem. Commun., 2014, 50, 2943
    DOI: 10.1039/C4CC00181H

Search articles by author

Spotlight

Advertisements