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Issue 54, 2014
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A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

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Abstract

We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a “light-up” and “spectrum-shift” response to target DNA in vitro and could further image the tumor-related mRNA in living cells.

Graphical abstract: A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

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Publication details

The article was received on 08 Jan 2014, accepted on 21 Mar 2014 and first published on 21 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC00160E
Citation: Chem. Commun., 2014,50, 7107-7110
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    A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

    J. Li, J. You, Y. Zhuang, C. Han, J. Hu, A. Wang, K. Xu and J. Zhu, Chem. Commun., 2014, 50, 7107
    DOI: 10.1039/C4CC00160E

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