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Issue 28, 2014
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N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon–sulfur bonds

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Abstract

A novel N-heterocyclic carbene (NHC)-catalyzed formal cross-coupling reaction between α-haloenals and thiols was developed. In the presence of 5 mol% NHC precursors and 1.6 equiv. potassium carbonate, various thiols coupled with α-haloenals to produce α-thioenals in 53% to 91% yield and excellent Z-selectivity.

Graphical abstract: N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon–sulfur bonds

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Publication details

The article was received on 08 Jan 2014, accepted on 11 Feb 2014 and first published on 13 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00154K
Citation: Chem. Commun., 2014,50, 3719-3721
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    N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon–sulfur bonds

    L. He, H. Guo, Y. Li, G. Du and B. Dai, Chem. Commun., 2014, 50, 3719
    DOI: 10.1039/C4CC00154K

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