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Issue 27, 2014
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Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

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Abstract

A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C–N and C–O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source.

Graphical abstract: Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

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Publication details

The article was received on 26 Dec 2013, accepted on 04 Feb 2014 and first published on 06 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49788G
Citation: Chem. Commun., 2014,50, 3609-3611
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    Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

    J. Zheng, M. Zhang, L. Huang, X. Hu, W. Wu, H. Huang and H. Jiang, Chem. Commun., 2014, 50, 3609
    DOI: 10.1039/C3CC49788G

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