Issue 22, 2014
From the journal:

Chemical Communications

Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene†

Hui Zhang,*a   Meixing Li,a   Mengxing Fan,a   Jinxing Gu,a   Ping Wua  and  Chenxin Cai*a  

* Corresponding authors

a Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
E-mail: zhangh@njnu.edu.cn, cxcai@njnu.edu.cn
Fax: +86 25 85891767
Tel: +86 25 85891780

Abstract

We report a new strategy for detection of the methylation level and position in the Hsp53 tumor suppressor gene based on the electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for improving selectivity.

Graphical abstract: Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene

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Article information

DOI
https://doi.org/10.1039/C3CC49719D
Article type
Communication
Submitted
23 Dec 2013
Accepted
23 Jan 2014
First published
24 Jan 2014

Chem. Commun., 2014,50, 2932-2934

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Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene

H. Zhang, M. Li, M. Fan, J. Gu, P. Wu and C. Cai, Chem. Commun., 2014, 50, 2932 DOI: 10.1039/C3CC49719D

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