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Issue 22, 2014
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Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

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Abstract

The dearomatising dihydroxylation of aromatic molecules mediated by arene dioxygenase enzymes can provide cyclohexadiene-diols that are versatile starting materials for organic synthesis. Whereas oxidation of a substituted arene to give its ortho,meta-dihydrodiol has been demonstrated for numerous substrates and dioxygenases, formation of ipso,ortho-dihydrodiols has historically been underutilised in comparison. This feature article presents a chronological account of reported uses of such diols.

Graphical abstract: Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

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Publication details

The article was received on 21 Dec 2013, accepted on 05 Feb 2014 and first published on 11 Feb 2014


Article type: Feature Article
DOI: 10.1039/C3CC49694E
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 2821-2830
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    Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

    S. E. Lewis, Chem. Commun., 2014, 50, 2821
    DOI: 10.1039/C3CC49694E

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