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Issue 22, 2014
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Tritium labeling of detonation nanodiamonds

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For the first time, the radioactive labeling of detonation nanodiamonds was efficiently achieved using a tritium microwave plasma. According to our measurements, the total radioactivity reaches 9120 ± 120 μCi mg−1, with 93% of 3H atoms tightly bonded to the surface and up to 7% embedded into the diamond core. Such 3H doping will ensure highly stable radiolabeled nanodiamonds, on which surface functionalization is still allowed. This breakthrough opens the way to biodistribution and pharmacokinetics studies of nanodiamonds, while this approach can be scalable to easily treat bulk quantities of nanodiamonds at low cost.

Graphical abstract: Tritium labeling of detonation nanodiamonds

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Publication details

The article was received on 20 Dec 2013, accepted on 24 Jan 2014 and first published on 27 Jan 2014

Article type: Communication
DOI: 10.1039/C3CC49653H
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 2916-2918
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    Tritium labeling of detonation nanodiamonds

    H. A. Girard, A. El-Kharbachi, S. Garcia-Argote, T. Petit, P. Bergonzo, B. Rousseau and J. Arnault, Chem. Commun., 2014, 50, 2916
    DOI: 10.1039/C3CC49653H

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