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Issue 20, 2014
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Reconstitution of OmpF membrane protein on bended lipid bilayers: perforated hexagonal mesophases

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Abstract

Membrane proteins have been reconstituted on lipid bilayers with zero mean-curvature (cubic phases or vesicles). Here we show that reconstitution of pore-forming membrane proteins can also occur on highly curved lipidic bilayers of reverse hexagonal mesophases, for which the mean-curvature is significantly different from zero. We further show that the membrane protein provides unique topological interconnectivities between the aqueous nanochannels, significantly enhancing mesophase transport properties.

Graphical abstract: Reconstitution of OmpF membrane protein on bended lipid bilayers: perforated hexagonal mesophases

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Publication details

The article was received on 18 Dec 2013, accepted on 09 Jan 2014 and first published on 10 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC49590F
Citation: Chem. Commun., 2014,50, 2642-2645
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    Reconstitution of OmpF membrane protein on bended lipid bilayers: perforated hexagonal mesophases

    A. Zabara, R. Negrini, P. Baumann, O. Onaca-Fischer and R. Mezzenga, Chem. Commun., 2014, 50, 2642
    DOI: 10.1039/C3CC49590F

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