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Issue 41, 2014
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Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

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Abstract

Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.

Graphical abstract: Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

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Publication details

The article was received on 17 Dec 2013, accepted on 03 Feb 2014 and first published on 26 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49543D
Citation: Chem. Commun., 2014,50, 5444-5446
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    Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

    H. Yamamura, Y. Sugiyama, K. Murata, T. Yokoi, R. Kurata, A. Miyagawa, K. Sakamoto, K. Komagoe, T. Inoue and T. Katsu, Chem. Commun., 2014, 50, 5444
    DOI: 10.1039/C3CC49543D

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