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Issue 40, 2014
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68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

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Abstract

We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Graphical abstract: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

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Publication details

The article was received on 16 Dec 2013, accepted on 19 Feb 2014 and first published on 21 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49530B
Citation: Chem. Commun., 2014,50, 5215-5217
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    68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

    B. Nichols, Z. Qin, J. Yang, D. R. Vera and N. K. Devaraj, Chem. Commun., 2014, 50, 5215
    DOI: 10.1039/C3CC49530B

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