Issue 30, 2014

Development of the crosslinking reactions to RNA triggered by oxidation

Abstract

A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

Graphical abstract: Development of the crosslinking reactions to RNA triggered by oxidation

Supplementary files

Article information

Article type
Communication
Submitted
13 Dec 2013
Accepted
18 Feb 2014
First published
18 Feb 2014

Chem. Commun., 2014,50, 3951-3954

Author version available

Development of the crosslinking reactions to RNA triggered by oxidation

S. Kusano, T. Haruyama, S. Ishiyama, S. Hagihara and F. Nagatsugi, Chem. Commun., 2014, 50, 3951 DOI: 10.1039/C3CC49463B

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