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Issue 31, 2014
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Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

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Abstract

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

Graphical abstract: Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

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Publication details

The article was received on 03 Dec 2013, accepted on 20 Feb 2014 and first published on 24 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49198F
Citation: Chem. Commun., 2014,50, 4096-4098
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    Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

    R. Ekambaram, E. Enkvist, G. B. Manoharan, M. Ugandi, M. Kasari, K. Viht, S. Knapp, O. Issinger and A. Uri, Chem. Commun., 2014, 50, 4096
    DOI: 10.1039/C3CC49198F

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