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Issue 31, 2014
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Reversible Ag+-crosslinked DNA hydrogels

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Abstract

DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag+-stimulated formation of cytosine–Ag+–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag+ ions dissociates the hydrogels into a solution phase.

Graphical abstract: Reversible Ag+-crosslinked DNA hydrogels

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Publication details

The article was received on 01 Dec 2013, accepted on 13 Feb 2014, published on 13 Feb 2014 and first published online on 13 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49140D
Citation: Chem. Commun., 2014,50, 4065-4068
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    Reversible Ag+-crosslinked DNA hydrogels

    W. Guo, X. Qi, R. Orbach, C. Lu, L. Freage, I. Mironi-Harpaz, D. Seliktar, H. Yang and I. Willner, Chem. Commun., 2014, 50, 4065
    DOI: 10.1039/C3CC49140D

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