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Issue 46, 2014
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Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

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Abstract

An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.

Graphical abstract: Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

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Publication details

The article was received on 28 Nov 2013, accepted on 14 Feb 2014 and first published on 19 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49080G
Citation: Chem. Commun., 2014,50, 6098-6100
  • Open access: Creative Commons BY license
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    Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

    N. Richter, R. C. Simon, W. Kroutil, J. M. Ward and H. C. Hailes, Chem. Commun., 2014, 50, 6098
    DOI: 10.1039/C3CC49080G

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