Issue 17, 2014
From the journal:

Chemical Communications

Synthesis of 6-acyl phenanthridines by oxidative radical decarboxylation–cyclization of α-oxocarboxylates and isocyanides†

Jie Liu,a   Chao Fan,a   Hongyu Yin,a   Chu Qin,a   Guoting Zhang,a   Xu Zhang,a   Hong Yia  and  Aiwen Lei*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China
E-mail: aiwenlei@whu.edu.cn
Tel: +86-27-68754672

b National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, P. R. China

Abstract

A silver catalysed synthesis of 6-acyl phenanthridines by oxidative radical decarboxylation–cyclization of α-oxocarboxylates and isocyanides was developed. This reaction provided a novel method to realize C1 insertion via a radical process and various functional groups were well-tolerated.

Graphical abstract: Synthesis of 6-acyl phenanthridines by oxidative radical decarboxylation–cyclization of α-oxocarboxylates and isocyanides

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Article information

DOI
https://doi.org/10.1039/C3CC49026B
Article type
Communication
Submitted
26 Nov 2013
Accepted
26 Dec 2013
First published
06 Jan 2014

Chem. Commun., 2014,50, 2145-2147

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Synthesis of 6-acyl phenanthridines by oxidative radical decarboxylation–cyclization of α-oxocarboxylates and isocyanides

J. Liu, C. Fan, H. Yin, C. Qin, G. Zhang, X. Zhang, H. Yi and A. Lei, Chem. Commun., 2014, 50, 2145 DOI: 10.1039/C3CC49026B

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