Issue 15, 2014
From the journal:

Chemical Communications

Selective monomethylation of primary amines with simple electrophiles†

Thomas Lebleu,a   Xiaolu Ma,a   Jacques Maddalunoa  and  Julien Legros*a  

* Corresponding authors

a Normandie Univ, COBRA UMR 6014, Univ Rouen, INSA Rouen and CNRS, 1 rue Lucien Tesnière, 76821 Mont-Saint-Aignan, France
E-mail: julien.legros@univ-rouen.fr

Abstract

Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.

Graphical abstract: Selective monomethylation of primary amines with simple electrophiles

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Article information

DOI
https://doi.org/10.1039/C3CC48997C
Article type
Communication
Submitted
25 Nov 2013
Accepted
16 Dec 2013
First published
16 Dec 2013

Chem. Commun., 2014,50, 1836-1838

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Selective monomethylation of primary amines with simple electrophiles

T. Lebleu, X. Ma, J. Maddaluno and J. Legros, Chem. Commun., 2014, 50, 1836 DOI: 10.1039/C3CC48997C

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