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Issue 37, 2014
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Copper-mediated cross-coupling–cyclization–oxidation: a one-pot reaction to construct polysubstituted pyrroles

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Abstract

A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling–cyclization–oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis.

Graphical abstract: Copper-mediated cross-coupling–cyclization–oxidation: a one-pot reaction to construct polysubstituted pyrroles

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Publication details

The article was received on 15 Nov 2013, accepted on 16 Jan 2014 and first published on 22 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC48728H
Citation: Chem. Commun., 2014,50, 4795-4798
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    Copper-mediated cross-coupling–cyclization–oxidation: a one-pot reaction to construct polysubstituted pyrroles

    P. Liu, J. Liu, H. Wang, Y. Pan, H. Liang and Z. Chen, Chem. Commun., 2014, 50, 4795
    DOI: 10.1039/C3CC48728H

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