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Issue 39, 2014
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Direct N9-arylation of purines with aryl halides

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Abstract

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(I) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N9-position.

Graphical abstract: Direct N9-arylation of purines with aryl halides

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Publication details

The article was received on 12 Nov 2013, accepted on 10 Feb 2014 and first published on 12 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC48642G
Citation: Chem. Commun., 2014,50, 4997-4999
  • Open access: Creative Commons BY-NC license
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    Direct N9-arylation of purines with aryl halides

    A. F. Larsen and T. Ulven, Chem. Commun., 2014, 50, 4997
    DOI: 10.1039/C3CC48642G

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