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Issue 8, 2014
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Discovery of new G-quadruplex binding chemotypes

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Abstract

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

Graphical abstract: Discovery of new G-quadruplex binding chemotypes

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Publication details

The article was received on 11 Nov 2013, accepted on 29 Nov 2013 and first published on 02 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48616H
Citation: Chem. Commun., 2014,50, 960-963
  • Open access: Creative Commons BY license
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    Discovery of new G-quadruplex binding chemotypes

    S. A. Ohnmacht, E. Varavipour, R. Nanjunda, I. Pazitna, G. Di Vita, M. Gunaratnam, A. Kumar, M. A. Ismail, D. W. Boykin, W. D. Wilson and S. Neidle, Chem. Commun., 2014, 50, 960
    DOI: 10.1039/C3CC48616H

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