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Issue 11, 2014
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Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

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Abstract

We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

Graphical abstract: Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

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Publication details

The article was received on 11 Nov 2013, accepted on 26 Nov 2013 and first published on 28 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48587K
Citation: Chem. Commun., 2014,50, 1341-1343
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    Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

    H. Yamakoshi, A. F. Palonpon, K. Dodo, J. Ando, S. Kawata, K. Fujita and M. Sodeoka, Chem. Commun., 2014, 50, 1341
    DOI: 10.1039/C3CC48587K

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