Jump to main content
Jump to site search

Issue 18, 2014
Previous Article Next Article

Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones

Author affiliations

Abstract

The first enantioselective conjugate alkynylation of β-trifluoromethyl α,β-enones using terminal alkynes and a taniaphos–Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the β-position were obtained with good yields and high enantiomeric excesses (up to 99%).

Graphical abstract: Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Nov 2013, accepted on 27 Dec 2013 and first published on 06 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC48508K
Citation: Chem. Commun., 2014,50, 2275-2278
  •   Request permissions

    Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones

    A. Sanz-Marco, A. García-Ortiz, G. Blay and J. R. Pedro, Chem. Commun., 2014, 50, 2275
    DOI: 10.1039/C3CC48508K

Search articles by author

Spotlight

Advertisements