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Issue 15, 2014
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Structural insights into how 5-hydroxymethylation influences transcription factor binding

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Abstract

Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson–Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Graphical abstract: Structural insights into how 5-hydroxymethylation influences transcription factor binding

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Publication details

The article was received on 24 Oct 2013, accepted on 19 Nov 2013 and first published on 29 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48151D
Citation: Chem. Commun., 2014,50, 1794-1796
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    Structural insights into how 5-hydroxymethylation influences transcription factor binding

    L. Lercher, M. A. McDonough, A. H. El-Sagheer, A. Thalhammer, S. Kriaucionis, T. Brown and C. J. Schofield, Chem. Commun., 2014, 50, 1794
    DOI: 10.1039/C3CC48151D

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