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Issue 11, 2014
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Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

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Abstract

Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.

Graphical abstract: Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

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Publication details

The article was received on 23 Oct 2013, accepted on 26 Nov 2013 and first published on 27 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48130A
Citation: Chem. Commun., 2014,50, 1369-1371
  • Open access: Creative Commons BY license
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    Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

    D. Hofmann, C. Messerschmidt, M. B. Bannwarth, K. Landfester and V. Mailänder, Chem. Commun., 2014, 50, 1369
    DOI: 10.1039/C3CC48130A

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