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Issue 27, 2014
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A highly sensitive immunoassay using antibody-conjugated spherical mesoporous silica with immobilized enzymes

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Abstract

A highly sensitive immunoassay was developed by using antibody-conjugated spherical mesoporous silica with immobilized enzymes. The higher ratio of enzyme/antibody than conventional ELISA improved both the sensitivity and dynamic range. Especially, the use of spherical mesoporous silica could achieve a limit of detection (LOD) with a sensitivity that is 20 times more than that of ELISA using amorphous silica.

Graphical abstract: A highly sensitive immunoassay using antibody-conjugated spherical mesoporous silica with immobilized enzymes

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Publication details

The article was received on 19 Oct 2013, accepted on 04 Dec 2013 and first published on 04 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48044E
Citation: Chem. Commun., 2014,50, 3546-3548
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    A highly sensitive immunoassay using antibody-conjugated spherical mesoporous silica with immobilized enzymes

    J. Y. Eum, S. Y. Hwang, Y. Ju, J. M. Shim, Y. Piao, J. Lee, H. Kim and J. Kim, Chem. Commun., 2014, 50, 3546
    DOI: 10.1039/C3CC48044E

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