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Issue 4, 2014
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Nickel-mediated stereocontrolled synthesis of spiroketals via tandem cyclization–coupling of β-bromo ketals and aryl iodides

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Abstract

A ketal-tether approach for the stereoselective synthesis of [5,5] and [5,6]-spiroketals based on reductive coupling catalyzed by the readily available Ni complex is demonstrated. Either an intermolecular or an intramolecular stereospecific cascade has been achieved as well.

Graphical abstract: Nickel-mediated stereocontrolled synthesis of spiroketals via tandem cyclization–coupling of β-bromo ketals and aryl iodides

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Publication details

The article was received on 10 Oct 2013, accepted on 01 Nov 2013 and first published on 04 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47780K
Citation: Chem. Commun., 2014,50, 472-474
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    Nickel-mediated stereocontrolled synthesis of spiroketals via tandem cyclization–coupling of β-bromo ketals and aryl iodides

    Y. Peng, X. Xu, J. Xiao and Y. Wang, Chem. Commun., 2014, 50, 472
    DOI: 10.1039/C3CC47780K

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