Issue 8, 2014

Phosphine-catalyzed domino reaction: a novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives

Abstract

We have successfully developed a novel and efficient phosphine-catalyzed sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives. The protocol uses readily available γ-substituent allenoates as the starting materials, inexpensive PBu3 as the catalyst, and the corresponding products were obtained in good to excellent yields under mild conditions.

Graphical abstract: Phosphine-catalyzed domino reaction: a novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2013
Accepted
15 Nov 2013
First published
15 Nov 2013

Chem. Commun., 2014,50, 948-950

Phosphine-catalyzed domino reaction: a novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives

E. Li and Y. Huang, Chem. Commun., 2014, 50, 948 DOI: 10.1039/C3CC47716A

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